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摘要翻译：
提出了化学和物理诱导干细胞多能性的量子模型。基于构象哈密顿量和慢变量（分子扭转）奴役快变量的思想，把从微分态到多能态的转换定义为构象态之间的量子跃迁。计算了过渡速率，推导了过渡速率公式的解析形式。然后，通过与蛋白质折叠的比较，可以估计速率与基因扭转角个数和速率大小的依赖关系。给出了化学重编程过程中多能性基因构象变化的反应方程。计算了化学重编程的特征时间，结果与实验相符。从速率方程出发，分析了温度、PH值、相干畴体积和形状等物理因素对转变速率的影响。因此，通过降低某些多能性基因的一致性程度，可以为物理诱导多能性提供更有效的途径。
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英文标题：
《A Quantum Model on Chemically-Physically Induced Pluripotency in Stem
Cells》
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作者：
Liaofu Luo
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最新提交年份：
2015
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分类信息：
一级分类：Quantitative Biology 数量生物学
二级分类：Other Quantitative Biology 其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
A quantum model on the chemically and physically induced pluripotency in stem cells is proposed. Based on the conformational Hamiltonian and the idea of slow variables (molecular torsions) slaving fast ones the conversion from the differentiate state to pluripotent state is defined as the quantum transition between conformational states. The transitional rate is calculated and an analytical form for the rate formulas is deduced. Then the dependence of the rate on the number of torsion angles of the gene and the magnitude of the rate can be estimated by comparison with protein folding. The reaction equations of the conformational change of the pluripotency genes in chemical reprogramming are given. The characteristic time of the chemical reprogramming is calculated and the result is consistent with experiments. The dependence of the transition rate on physical factors such as temperature, PH value and the volume and shape of the coherent domain is analyzed from the rate equation. It is suggested that by decreasing the coherence degree of some pluripotency genes a more effective approach to the physically induced pluripotency can be made.
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PDF链接：
https://arxiv.org/pdf/1309.7546
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