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摘要翻译：
我们提出了一类微观结构信息模型，用于交联聚合物网络，如肌动蛋白细胞骨架的线弹性力学行为。该模型的显著特点包括：可以表示各向异性纤维分布所导致的各向异性力学行为，以及力学性能随纤维密度的幂律标度。类内的力学模型由七个不同的常数参数化。我们演示了用三维肌动蛋白网络的有限元模型来确定这些常数的过程。将肌动蛋白丝和交联体模拟成弹性棒，并以生理体积分数和图像体素的尺度构建网络。我们展示了该模型在较宽的纤维密度和各向异性程度范围内估计网络力学行为的性能。
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英文标题：
《A microstructurally informed model for the mechanical response of
three-dimensional actin networks》
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作者：
Ronald Y. Kwon, Adrian J. Lew, Christopher R. Jacobs
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最新提交年份：
2008
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分类信息：
一级分类：Quantitative Biology 数量生物学
二级分类：Other Quantitative Biology 其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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一级分类：Quantitative Biology 数量生物学
二级分类：Subcellular Processes 亚细胞过程
分类描述：Assembly and control of subcellular structures (channels, organelles, cytoskeletons, capsules, etc.); molecular motors, transport, subcellular localization; mitosis and meiosis
亚细胞结构（通道、细胞器、细胞骨架、囊膜等）的组装和控制；分子马达；转运；亚细胞定位；有丝分裂和减数分裂
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英文摘要：
We propose a class of microstructurally informed models for the linear elastic mechanical behavior of cross-linked polymer networks such as the actin cytoskeleton. Salient features of the models include the possibility to represent anisotropic mechanical behavior resulting from anisotropic filament distributions, and a power-law scaling of the mechanical properties with the filament density. Mechanical models within the class are parameterized by seven different constants. We demonstrate a procedure for determining these constants using finite element models of three-dimensional actin networks. Actin filaments and cross-links were modeled as elastic rods, and the networks were constructed at physiological volume fractions and at the scale of an image voxel. We show the performance of the model in estimating the mechanical behavior of the networks over a wide range of filament densities and degrees of anisotropy.
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PDF链接：
https://arxiv.org/pdf/0802.3744
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