The study will enroll 12 subjects to ensure 10 completers. The sample size of 10 completers will provide 90% confidence intervals (CIs) for the difference between treatments of 0.098 on the natural log scale for AUCinf with 90% coverage probability. The following table presents the width of 90% confidence interval for different estimates of bioavailability:
The above calculations are based on estimates of within-subject standard deviations of 0.091 for loge AUCinf.


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