摘要翻译:
提出了一个通用的理论框架来组织和理解分子生物学领域中观察到的各种现象和数学关系。通过将真核生物中的每个细胞建模为一个处理器,它具有一组独特的允许状态,由特定的DNA序列表示,我们展示了一种可以调节基因表达的方法。随着理论的发展,我们提出了大多数真核生物使用互补的第四纪(4碱基)编码方案的原因。转座元件的作用,以及非编码DNA的丰富的作用,以及一个明确定义的方法,通过单核苷酸多态性(SNP)可能改变基因表达。考虑了各种误差的影响。最后,提出了一种处理器间通信机制来解释细胞-细胞识别过程,从而阐明了非诱变致癌剂可能作用的可能途径。
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英文标题:
《Dynamic DNA Processing: A Microcode Model of Cell Differentiation》
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作者:
Barry D. Jacobson
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最新提交年份:
2013
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分类信息:
一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
A general theoretical framework is put forth to organize and understand various observed phenomena and mathematical relationships in the field of molecular biology. By modeling each cell in eukaryotic organisms as a processor having a unique set of allowed states, represented by a specific DNA sequence, we demonstrate a method by which gene expression can be regulated. As the theory is developed, we suggest reasons for the complementary, quaternary (4-base) coding scheme used in most eukaryotes. A role for transposable elements is suggested, as is a role for the abundance of noncoding DNA, along with a clearly-defined method by which single nucleotide polymorphisms (SNP's) may alter gene expression. The effect of various errors is considered. Finally, a mechanism for inter-processor communication is proposed to explain cell-cell recognition processes, which leads to an elucidation of a possible pathway by which nonmutagenic carcinogenic agents may act.
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PDF链接:
https://arxiv.org/pdf/1312.4902