摘要翻译:
一些作者认为,非线性激发,特别是孤立波,在DNA转录过程中起着基本的功能作用,影响RNA聚合酶复制遗传密码所需的双链的打开。一些模型已经被提出来根据减少的有效自由度数来模拟相关的DNA动力学。这里我讨论了这种方法的优点和缺点,并更详细地讨论了其中的一个模型,即Yakushevich提出的模型。
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英文标题:
《Results and Limitations of the Soliton Theory of DNA Transcription》
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作者:
G. Gaeta
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最新提交年份:
2003
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分类信息:
一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
It has been suggested by several authors that nonlinear excitations, in particular solitary waves, could play a fundamental functional role in the process of DNA transcription, effecting the opening of the double chain needed for RNA Polymerase to be able to copy the genetic code. Some models have been proposed to model the relevant DNA dynamics in terms of a reduced number of effective degrees of freedom. Here I discuss advantages and disadvantages of such an approach, and discuss in more detail one of the models, i.e. the one proposed by Yakushevich.
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PDF链接:
https://arxiv.org/pdf/q-bio/0312024