相关背景:
This model selects for the minimum residual SE in a stepwise partitioning of data points between 2 regression lines. The first regression line has a slope and the second line is horizontal with minimal or no slope. The mixed procedure takes into account the correlations among observations made on the same participant and the possible heterogeneous variances among the measurements made on the same participant over time and is well suited for repeated-measures study designs (25). Different variancecovariance structures (simple, compound symmetry, unstructured, first order auto-regressive, and first order ante-dependence) were compared using the information criteria (Akaike Information Criteria, the finite sample corrected Akaike Information Criteria, and the Schwarz’s Bayesian Information Criteria). The final model that best fit the data with the lowest SE, lowest root mean square error, and highest r2 identified the breakpoint estimate or requirement for lysine. The safe
intake of lysine (upper 95% CI, equivalent to the Recommended Dietary Allowance) was calculated using Fieller’s theorem (26). Briefly, 95% CI = breakpoint 6 tdf,a/2 3 SE, where SE is the SE of the breakpoint, df is associated with the residual mean square of the best fit model, and a is the 95% confidence level. Upper 95% CI was calculated using SAS (SAS/STAT version 8.2, SAS Institute).



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