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bigpumpkin (whocares) 于Fri Dec 21 15:47:25 2007)
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鉴于南京大学在教授招聘过程中严重不公正，南京大学从今天16：10之停止一切活动。
同
时，我从现在起辞去南京大学模式动物研究所所长职务和教授职务。特此通告。
南京大学模式动物研究所 高翔
------------------------------- 在学校里的时间越长，心里越担心，担心做人的底线被突破。每天都有很多不知不觉 地“习以为常”产生，而这些“习以为常”是几年前无法想象的。每天也都由些不大不 小 的消息，麻醉着原已很疲惫的神经。我担心的是那条文人学者的底线究竟是什么？我能 守 得住吗？ 有多少昨日的所谓知书达礼的弟兄，到如今发现其实比在官场上纵横几十年的官僚 更 无耻，因为这些刚归国的“海龟”们对官场的荣耀还不如那些土鳖看的透明。一旦海龟 开 始追逐功名，好像很少有底线的。于是，看着一个个旧友成野狗，无可奈何！ |
-------------------------------------------------- 高 翔 PhD “长江学者奖励计划”特聘教授，博士生导师 ，南京大学模式动物研究所所长 电话 办公室：58641598 实验室：58641511 电子邮件 ： gaox@nicemice.cn 研究兴趣： 主要研究方向为细胞生物学、发育生物学、小鼠遗传学; 主要学术成果：①结合化学诱 变 和表型筛选，建立20余种遗传性疾病的小鼠模型并克隆突变基因；②证明蛋白磷酸酶 PRL- 3基因在肿瘤转移过程中的关键作用，发现下游信号因子；③对内质网紧张诱导的神经元 凋 亡进行分析；④运用干细胞移植治疗心肌坏死和促进新血管形成；⑤证明Notch信号传导 调 节血管重塑过程和抑制寡突胶质细胞分化；⑥发现干扰素抑制寡突胶质细胞凋亡；⑦发 现 p53和bcl-2基因对DNA损伤诱导细胞凋亡的调控作用及其对胚胎发育的影响。 代表论文： A. Research papers (*Correspondence author) 1. Xiong X, Qi X, Ge XM, Gu P, Zhao J, Zhao QS, *Gao X.(2007) A novel Phex mutation with defective glycosylation causes hypophosphatemia and rickets i n mice. J Biomed Sci, in press 2. Sha HB, Xu J, Tang J, Ding J, Gong JF, Ge XM, Kong D, *Gao X. (2007) D isruption of a novel regulatory locus results in decreased Bdnf expression, ob esity and type 2 diabetes in mice. Physiological Genomics, in press 3. Qi X, Yang G, Yang L, Lan Y, Weng T, Wang J, Wu Z, Xu J, *Gao X, *Yan g X. (2007)Essential role of Smad4 in maintaining cardiomyocyte proliferation during murine embryonic heart development. Dev Biol, in press 4. Zeng H, Di L, Fu GP, Chen YH, Gao X, Xu L, Lin X, Wen RR (2007) Phosp horylation of Bcl10 negatively regulates T cell receptor-mediated NF-kB activa tion. Mol Cell Biol, 27:5235-45 5. Liu X, Chen Y, Zhang F, Chen L, Ha T, Gao X, Li C. Synergistically th erapeutic effects of VEGF165 and angiopoietin-1 on ischemic rat myocardium. Sc and Cardiovasc J. 2007 Apr;41(2):95-101. 6. Hua F, Ha T, Ma J, Li Y, Kelley J, Gao X, Browder IW, Kao RL, William s DL, Li C (2007) Protection against Myocardial Ischemia/Reperfusion Injury in TLR4-Deficient Mice Is Mediated through a Phosphoinositide 3-Kinase- Dependent Mechanism. J Immunol, 178:7317-24. 7. Liu L, Zhang X, Qian B, Min X, Gao X, Li C, Cheng Y, Huang J (2007) O ver-expression of heat shock protein 27 attenuates doxorubicin-induced cardiac dysfunction in mice. Eur J Heart Fail., in press 8. Tan X, Weng T, Zhang J, Wang J, Li W, Wan H, Lan Y, Cheng X, Hou N, L iu H, Ding J, Lin F, Yang R, Gao X, Chen D, Yang X（2007）Smad4 is required fo r maintaining normal murine postnatal bone homeostasis. J Cell Sci 120: 2162- 2 170; 9. Chen JY, Schopf JW, Bottjer DJ, Zhang CY, Kudryavtsev AB, Tripathi AB , Wang XQ, Yang YH, Gao X, Yang Y (2007) Raman spectra of a Lower Cambrian cte nophore embryo from southwestern Shaanxi, China. PNAS 104: 6289-6292; 10. Zhang D, Zhang F, Zhang Y, Gao X, Li C, Yang N, Cao K (2007) Combining erythropoietin infusion with intramyocardial delivery of bone marrow cells is more effective for cardiac repair. Transpl Int. 20:174-83. 11. Fan Y, Liu X, Zhang H, Dai J, Zhang X, Zhu M, Gao X, Wang Y (2006) Var iations in exon 7 of the MSH2 gene and susceptibility to gastrointestinal canc er in a Chinese population. Cancer Genet Cytogenet. 170:121-8. 12. Gu X, Xu F, Song W, Yang Y, Hu P, Wang X, Gao X, Zhao Q (2006) A novel cytochrome P450, zebrafish Cyp26D1, involved in metabolism of all-trans retin oic acid, Molecular Endocrinology, 20:1661-72. 13. Chen JY, Bottjer DJ, Davidson EH, Dornbos SQ, Gao X, Li CW, Yang YH, L i G, Wang XQ, Xian DC, Wu RH, Hwu YK (2006) Phosphatized polar-lobe-forming em bryos from the Precambrian of southwest China. Science, 312: 1644-1646 14. Zhang D, Zhang F, Zhang Y, Gao X, Li C, Ma W, Cao K. (2006) Erythropoi etin enhances the angiogenic potency of autologous bone marrow stromal cells i n a rat model of myocardial Infarction. Cardiology. 108:228-236 15. Yu M, Sha H, Gao Y, Zeng H, Zhu M, Gao X* (2006) Alternative 3’ UTR p olyadenylation of Bzw1 transcripts display differential translation efficiency and tissue-specific expression. Biochem Biophys Res Commun. 345:479-85 16. Yang CX, Chen HQ, Chen C, Yu WP, Zhang WC, Peng YJ, He WQ, Wei DM, Gao X, Zhu MS (2006) Microfilament-binding properties of N-terminal extension of the isoform of smooth muscle long myosin light chain kinase. Cell Res, 16:367- 76 17. Zhu Y, Zeng H, Gao X, Lu ZH (2006) Quantitative analysis of EcoR1 meth ylase-DNA complex by atomic force microscopy. Scanning 28: 15-19 18. Ha T, Li Y, Gao X, McMullen JR, Shioi T, Izumo S, Kelley JL, Zhao A, H addad GE, Williams DL, Browder IW, Kao RL, Li C. (2005) Attenuation of cardiac hypertrophy by inhibiting both mTOR and NFkB activation in vivo. Free Radica l Biology & Medicine, 39:1570-80 19. Hua F, Ha T, Ma J, Gao X, Kelley J, Williams DL, Browder IW, Kao RL, L i C.(2005) Blocking the MyD88-dependent pathway protects the myocardium from i schemia/reperfusion injury in rat hearts. Biochem Biophys Res Commun. 338:1118 -25 20. Ha T, Hua F, Li Y, Ma J, Gao X, Kelley J, Zhao A, Haddad GE, Williams DL, Browder IW, Kao RL, Li C. (2005) Blockade of MyD88 Attenuates Cardiac Hype rtrophy and Decreases Cardiac Myocyte Apoptosis in Pressure Overload Induced C ardiac Hypertrophy in vivo. Am J Physiol Heart Circ Physiol., 290(3):H985-94 21. Ha T, Li Y, Hua F, Ma J, Gao X, Kelley J, Zhao A, Haddad GE, Williams DL, William Browder I, Kao RL, Li C. (2005) Reduced cardiac hypertrophy in tol l-like receptor 4-deficient mice following pressure overload. Cardiovasc Res. 68:224-34. 22. Gu X, Xu F, Wang X, Gao X, Zhao Q. (2005) Molecular cloning and expres sion of a novel CYP26 gene (cyp26d1) during zebrafish early development. Gene Expr Patterns 5:733-9 23. Yang G, Cui F, Hou N, Chen X, Zhang J, Wang Y, Jiang N, Gao X, Yang X (2005) Transgenic Mice That Express Cre Recombinase in Differentiated Hypertro phic Chondrocytes, Genesis, 42:33-6 24. Ruan H, Zhang N, *Gao X (2005) Identification of a novel point mutatio n of mouse proto-oncogene c-kit through N-ethyl-N-nitrosourea (ENU) mutagenesi s. Genetics, 169:819-31 25. Zhou L, Ma W, Yang Z, Zhang F, Lu L, Ding Z, Ding B, Ha T, *Gao X, *Li C. (2005) VEGF(165) and angiopoietin-1 decreased myocardium infarct size thr ough phosphatidylinositol-3 kinase and Bcl-2 pathways. Gene Ther. 12:196-202 26. Wu X, Zeng H, Zhang X, Zhao Y, Sha H, *Gao X, *Xu Q. (2004) PRL-3 prom otes motility and metastasis of mouse melanoma cells. Am J. Path. 164: 2039 27. Wen C, Xue B, Qin X, Yu M, Zhang M, Zhao D, Gao X, Gu J, Li C. (2004) NRAGE suppress cell proliferation though a p53 dependent pathway. FEBS Lett. 5 64: 171 28. Li C, Ha T, Gao X, Kelley J, Browder W, Williams DL. (2004) NFkB activ ation is required for the development of cardiac hypertrophy in vivo. Am J Phy s: Heart and Circulatory Physiology. 287 : H1712 29. Li C, Ha T, Kelley J, Gao X, Qiu Y, Kao RL, Browder W, Williams DL. (2 004) Modulating Toll-like receptor mediated signaling by (1-->3)-beta-d- glucan rapidly induces cardioprotection. Cardiovasc Res. 61:538 30. Zhu Y, Zheng H, Xie JM, Ba L, Gao X, Lu Z (2004) AFM studies on DNA st ructural changes induced by vincristine sulfate and aspirin. Microscopy and Mi croanalysis 10:286 31. Zhang F, Yang Z, Chen Y, Qin J, Zhu T, Xu D, Xu Z, Xu Q, Qian Y, Ma W, Chen L, Gao X, Li C, Ha T, Kao RL. (2003) Clinical cellular cardiomyoplasty: technical considerations. J Card Surg.18:268 32. He F, Wang Z, Zhao J, Bao J, Ding J, Ruan H, Xie Q, Zhang Z, *Gao X. ( 2003) Large- scale screening of disease model through ENU mutagenesis in mice. Chinese Science Bulletin. 24:2665 33. Kao RL, Zhang FM, Yiang ZJ, Gao X, Li CF (2003) Cellular cardiomyoplas ty using autologous satellite cells: from experimental to clinical study. Basi c Appl. Myol. 13:1 34. Zhang F, Chen Y, Yang Z, Gao X, Ma W, Li C, Kao RL (2003) Cellular car diomyoplasty for a patient with heart failure. Cardiovascular Radiation Medici ne 4: 43 35. Zhang F, Gao X, Yiang ZJ, Ma W, Li C, Kao RL (2003) Cellular cardiomyo plasty: A preliminary clinical report. Cardiovascular Radiation Medicine 4: 39 36. Jiang P, Chen L, Liu J, Ding J, Gao X and Guo ZJ (2002) Novel zinc flu orescent probe bearing dansyl and aminoquinoline groups. Chemical Communicatio n 2002:1424 37. Chen LZ and *Gao X (2002), Neuronal apoptosis induced by endoplasmic r eticulum stress. Neurochemical Research, 27:891 38. McCright B, Gao X, Shen L, Lozier J, Lan Y, Maguire M, Herzlinger D, W eimaster G, Jiang R and Gridley T. (2001) Defects in development of the kidney , heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutati on. Development, 128:491 39. Gao X, Gillig TA, Ye P, D’Ercole AJ, Matsushima GK and Popko B. (2000 ) Interferon-gamma protects against Cuprizone-induced demyelination. Mol & Ce ll Neurosci. 16:338-49 40. Xue Y, Gao X (co-first author), Lindsell CE, Norton CR, Chang B, Hicks C, Gendron-Maguire M, Rand EB, Weinmaster G and Gridley T (1999) Embryonic Le thality and vascular defects in mice lacking the Notch ligand Jagged 1. Hum M ol Genet 8:723-30 41. Gao X, Copeland NG, Gilbert DJ, Jenkins NA and Gridley T, (1998) Assig nment of the murine Notch2 and Notch3 gense to chromosomes3 and 17. Genomics 4 9:60-1 42. Wubah JA,Ibrahim MM,Gao X, Pisano MM and Knudsen TB (1996) Teratogen- i nduced eye defect is mediated by p53-dependent embryonic apoptosis. Current Bi ology 6:60-9 43. Gao X, Knudsen TB, Ibrahim MM and Haldar S. (1995) Bcl-2 relieves deox yadenylate stress and suppresses apoptosis in pre-B leukemia cells. Cell Death and Differentiation 2:69-77 44. Gao X, Blackburn MR and Knudsen TB. (1994) Activation of apoptosis by 2'-deoxyadenosine in mouse early postimplantation embryos. Teratology 49:1-12 45. Blackburn MR, Gao X, Airhart MJ, Skalko RG, Thompson LF, Knudsen TB. ( 1992) Adenosine levels in the postimplantation mouse uterus: quantitation by H PLC-fluorometric detection and spatiotemporal regulation by 5'-nucleotidase an d adenosine deaminase. Dev Dyn. 194:155-68 46. Liu JN, Lu L, Gao X, Wang J, Zhu D, Lai LH, Xu XJ, Tang YQ. (1992) The structure basis of the poor fibrin specificity of urokinase (I)- knowledgebase d prediction of Kringle structures of urokinase and its related proteins. Sci China, Series B, 35:176-82 47. 郑一守, 秦国强, 高翔, 刘杰, 丁琪, 张梅芬, 姚建华 (1986) 抗体形成细胞发育 的 免疫组织化学研究．实验生物学报，19 : 327—337 B.Books and reviews: 1. 高翔：小鼠ENU化学诱变和QTL分析在疾病研究中的应用，in 基因工程小鼠，p95- 115 ，傅继梁主编，上海科学技术出版社 2．高翔，迟慧梅：生命的起源与进化，p92-97；高翔：生物技术在医学中的应用， p118- 126，in 生物医学导论，吴观陵主编，人民卫生出版社 3．Gao X, Kemper A and Popko B. (1999) Advanced transgenic and gene- targeting approaches. Neurochem. Res. 24:1181-8 实验室成员： 技术员: 李瑶 悦，齐心，周玥，蒋璇，闫果林，陈辉，卢在恋，魏晓为，杨军。 请进入高翔博士个人主页 请进入实验室主页 |
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