I hope to get pooled Dunnett adjusted confidence intervals from multiple imputed datasets. I first create 100 imputed datasets using PROC MI. Then I get the Dunnett adjusted CIs for treatment effect difference of A vs. C and B vs. C using Estimate statement with adjust=dunnett option in PROC MIXED. But it seems it’s not feasible to use PROC MIANALYZE to pool the Dunnett adjusted upper/lower limits or request an Dunnett adjustment to the CIs from PROC MIANALYZE?Can anyone give me some advice? Many thanks!
Below is my SAS code:
PROC MI data=toimp out=anami seed=124695 nimpute=100; by TRT ; var BASE w3 w5 w7 w9 w13 w17; EM maxiter=1000; mcmc chain=multiple impute=full; run;
PROC MIXED data=anami; class TRT; model week17 = TRT BASE / solution; lsmeans TRT/ADJUST=DUNNETT cl pdiff=control("C"); ods output Diffs=lsdiffs LSMeans=lsm solutionF=Parms; by _Imputation_; run;
PROC MIANALYZE parms(classvar=full)=lsdiffs; class TRT; modeleffects TRT; ods output ParameterEstimates=MIAN_lsdiffs; run;