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2014-12-07
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KEY WORDS: Biopharmaceutical classification system; dissolution ; bioavailability; bioequivalence; in vivo-in vitro relationship
ABSTRACT OBJECTIVE: To summarize the research and evaluation methods between in vivo and in vitro of drugs and their relationships; METHODS: To analyze the domestic and overseas relative literatures; RESULTS: Known by summarizing the basic research and evaluation methods of dissolution and bioavailability/bioequivalence, the aim of researching the IVIVC is to set up the in-vitro quality standard which can illustrate the bioavailability and the QC index between batch and batch in production; CONCLUSION: The dissolution results of drugs can predict it¡¯s bioavailability if the relationship between in-vivo data and in-vitro metric is fine.
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