西安交通大学研究生导师信息：李相尧-经管之家官网！

免费学术公开课,扫码加入

西安交通大学研究生导师信息：李相尧

Principal Investigator at the level of Professor

Jointly a deputy director of a lab (实验室副主任),

Lab of Neuronal Circuitry and Disease

(神经回路与疾病实验室)

E-mail: lixiangy9@mail.xjtu.edu.cn

Chronic pain is a major health issue in human society caused mainly by tissue or nerve injury. The common pathological conditions include spontaneous pain, allodynia and hyperalgesia. Peripheral sensitization and central plasticity are likely to contribute to chronic pain. The long-term change of the synaptic transmission induced by chronic pain has been studied along the sensory pathway, from the periphery receptors, spinal cord to the anterior cingulate cortex. Different approaches will be employed to investigate the  neuronal mechanism mediating the maintenance of chronic pain.

Name Xiang-Yao LI   

Sex Male

Birth  ,1978.1

Address Frontier Institute of Science and Technology,

Xi’an jiaotong University,

Rm. B316, West Building No.1,No.99 Yanxiang RD, Xi’an

Shaanxi, 710054, China

Phone  86-29-83395342

E-mail, Leexiangyao@gmail.com

Education:

2002-2007, Ph.D 

Neurophysiology, School of Life Science

East China Normal University, Shanghai, China

1996-2000,   Bachelor

Biology, Department of Biology

East China Normal University, Shanghai, China

Research and Working Experience: 

2012/03-presentFIST

Xi’an Jiaotong University

2007/12-2012/03    Post-doctoral Fellow (Prof. Min Zhuo)

Department of Physiology

University of Toronto

2006/5 – 2007/10    Visiting student (Prof. Shumin Duan)
 
Lab of Synapse Development & Plasticity

Institute of Neuroscience

2002/9 – 2007/6Graduate Student ( Prof. Xin-De Sun)

School of Life Science.

Research center for brain science,

East China Normal University, Shanghai, China

2000/7-2002/8   Assistant Teacher

Biology Department

Nanyang Teacher’s College, Henan, China

1999/12 – 2000/6    Visiting Student

Lab of Biophysics (Prof. Zhuan Zhou )

Institute of Neuroscience

Chinese Academy of Sciences, China

Fellowship:

2010/4 - 2012/04Post-doctoral fellowship from CIHR &

Fragile X research foundation of Canada

Research interests

1.The temporal processing of information in central nervous system.

The central nervous system is one of the most important parts of human.  The neurons in central nervous system process information from peripheral nervous system. The temporal properties of spikes carry critical information, which has been found to be involved in the brain function under normal and disease condition.  My group will combine different approach to investigate how the temporal summation of information coding is involved in the brain function.  

2.The energy metabolism of central nervous system under chronic pain condition.

Human brain imaging results suggest that the energy metabolism of pain related areas was changed under chronic pain condition. However, the cellular and molecular mechanism mediating this change kept unclear.  Energy metabolism has been proved to be involved in the maintenance of long-term memory, which shed a light that the energy metabolism is important for the maintenance of chronic pain, we therefore plan to combine different approaches to investigate the related mechanism mediating the change of energy metabolism under chronic pain condition.

Research articles and reviews

1.Li XY, Chen T, Descalzi G, Koga K, Qiu S, Zhuo M. Characterization of neuronal intrinsic properties and synaptic transmission in layer I of anterior cingulate cortex from adult mice, Molecular Pain.2012 8:53.

2.Descalzi G, Li XY, Chen T, Koga K, Mercaldo V, Kaang H, Zhuo M. Rapid alterations within the anterior cingulate cortex mediate trace fear learning. Molecular Brain. 2012 5:6.

3.Steenland H, Li XY, Zhuo M., Predicting Aversive Events and Terminating Fear in the Mouse Anterior Cingulate Cortex during Trace Fear Conditioning. J. Neurosci. 2012 32,(3):1082

4.Abumaria N, Yin B, Zhang L, Li XY, Chen T, Descalzi G, Zhao L, Ahn M, Luo L, Ran C, Zhuo M, Liu G. Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala. J. Neurosci. 2011, 31(42):14871-81.

5.Toyada H*, Li XY*, Wu LJ, Zhao MG, Descalzi G, Chen T, Koga K, Zhuo M. Interplay of amygdala and cingulate plasticity in emotional fear. Neural Plasticity. 2011, 2011:813749.  (*Equal contributor).

6.Koga K*, Chen T*, Li XY*, Descalzi G, Ling J, Gu J, Zhuo M. Glutamate acts as a neurotransmitter for GRP-related itch in mammalian spinal cord. Molecular Pain,7:47. (*Equal contributor).

7.Qiu S, Li XY, Zhuo M. Posttranslational modification of NMDA receptor GluN2B subunit and its roles in pain and memory. Seminars in Cell and Developmental Biology, 2011, 22(5):521-9.(review)

8.Li XY, Ko HY, Chen T, Collingridge GL, Kaang BK, Zhuo M. Erasing injury-related cortical synaptic potentiation as a new treatment for chronic pain. Journal of Molecular Medicine. 2011, 89(9):847-55 (review).

9.Kim SS*, Wang H*, Li XY* , Chen T*, Mercaldo V, Descalzi G, Wu LJ, Zhuo M. Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice. Molecular Brain. 2011, 4: 6. (*Equal contributor).

10.Li XY*, Ko HG*, Chen T*, Descalzi G, Koga K, Wang H, Kim SS, Shang Y, Kwak C, Park SW, Shim J, Lee K, Collingridge GL, Kaang BK, Zhuo M. Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex. Science. 2010; 330(6009):1400-4. (*Equal contributor, Science signaling Editor’s choice, Nature highlighted, F1000 highlighted )

11.Chen T, Koga K, Li XY, Zhuo M. Spinal microglial motility is independent of neuronal activity and plasticity in adult mice.  Molecular Pain. 2010; 6:19.

12.Wu LJ, Mellström B, Wang H, Ren M, Domingo S, Kim SS, Li XY, Chen T, Naranjo JR, Zhuo M. DREAM (Downstream Regulatory Element Antagonist Modulator) contributes to synaptic depression and contextual fear memory.  Molecular Brain. 2010; 3:3.

13.Koga K, Li XY, Chen T, Steenland HW, Descalzi G, Zhuo M. In vivo whole-cell patch-clamp recording of sensory synaptic responses of cingulate pyramidal neurons to noxious mechanical stimuli in adult mice. Molecular Pain. 2010; 6:62.

14.Cao XY, Xu H, Wu LJ, Li XY, Chen T, Zhuo M. Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury. Molecular Pain. 2009; 5:73

15.Wu LJ, Li XY, Chen T, Ren M, Zhuo M. Characterization of intracortical synaptic connections in the mouse anterior cingulate cortex using dual patch clamp recording. Molecular Brain. 2009; 2: 32.

16.Tong XP, Li XY, Zhou B. Shen W. Zhang ZJ. Xu TL. Duan S. Ca2+ signaling evoked by activation of Na+ channels and Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration. J. Cell Biol. 2009,186 (1): 113-128.

17.Vecsey CG. Baillie G. Jaganath D. Havekes R. Daniels A. Wimmer M. Huang T. Brown K. Li XY. Descalzi G. Kim SS. Chen T. Shang YZ. Zhuo M. Houslay MD. Abel T. Sleep deprivation impairs cAMP signaling in the hippocampus.2009. Nature. 2009; 461(7267):1122-5

18.Wu LJ*, Kim SS*, Li XY*, Zhang F*, Zhuo Min. Sexual attraction enhances glutamate transmission in mammalian anterior cingulate cortex. Molecular Brain, 2009; 1:9. (* Equal contributor)

19.Shang Y, Wang H, Mercaldo V, Li XY, Chen T, Zhuo M. Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice. J. Neurochem. 2009, 111(3): 635-46

20.Liao CY, Li XY, Wu B, Duan S. Jiang GBAcute enhancement of synaptic transmission and chronic inhibition of synaptogenesis induced by perfluorooctane sulfonate through mediation of voltage-dependent calcium channel. Environ. Sci. Technol. 2008, 42(14): 5335-41.

21.Li XY, Li L, Zhang JP, Sun XD. The behavioral presentations of audio-visual integration in rats. Academic journal of second military medical university, 2007, 28(5): 480-483.

22.Li XY, Gao F, Zhang Z, Zhang JP, Sun XD. Auditory cues induced the place navigation in rats. Journal of Fudan university (natural science edition), 2007, 46(6).

23.Gao F. Chen L. Pu Q. Li XY. Sun XD. Zhang JP. Influence of Prenatal Noise Exposure on the Auditory Object Exploration Behavior of Adult Rats. Chinese Journal of Zoology, 2007, 42(5): 20-26.

24.Wang XY, Yu LP, Li XY, Zhang JP, Sun XD. Auditory-visual Multisensory Neurons and Auditory-visual Information Integration in Newborn Rat Cortex. Chinese Journal of Zoology, 2006, 41(4): 31-40.

25.Yu LP, Wang XY, Li XY, Zhang JP, Sun XD. The Auditory-visual Multisensory Neurons and Auditory-visual Information Integration in Rat Cortex. Progress in Biochemistry and Biophysics, 2006, 33(7):677-684.

「经管之家」APP：经管人学习、答疑、交友，就上经管之家！
免流量费下载资料----在经管之家app可以下载论坛上的所有资源，并且不额外收取下载高峰期的论坛币。
涵盖所有经管领域的优秀内容----覆盖经济、管理、金融投资、计量统计、数据分析、国贸、财会等专业的学习宝库，各类资料应有尽有。
来自五湖四海的经管达人----已经有上千万的经管人来到这里，你可以找到任何学科方向、有共同话题的朋友。
经管之家（原人大经济论坛），跨越高校的围墙，带你走进经管知识的新世界。
扫描下方二维码下载并注册APP