南京大学模式动物研究所所长高翔教授不满学校辞职-经管之家官网！

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在学校里的时间越长，心里越担心，担心做人的底线被突破。每天都有很多不知不觉

地“习以为常”产生，而这些“习以为常”是几年前无法想象的。每天也都由些不大不
小

的消息，麻醉着原已很疲惫的神经。我担心的是那条文人学者的底线究竟是什么？我能
守

得住吗？
    有多少昨日的所谓知书达礼的弟兄，到如今发现其实比在官场上纵横几十年的官僚
更

无耻，因为这些刚归国的“海龟”们对官场的荣耀还不如那些土鳖看的透明。一旦海龟
开

始追逐功名，好像很少有底线的。于是，看着一个个旧友成野狗，无可奈何！

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高  翔  PhD

“长江学者奖励计划”特聘教授，博士生导师 ，南京大学模式动物研究所所长

电话

办公室：58641598

实验室：58641511

电子邮件 ：

gaox@nicemice.cn

研究兴趣：

主要研究方向为细胞生物学、发育生物学、小鼠遗传学; 主要学术成果：①结合化学诱
变
和表型筛选，建立20余种遗传性疾病的小鼠模型并克隆突变基因；②证明蛋白磷酸酶
PRL-
3基因在肿瘤转移过程中的关键作用，发现下游信号因子；③对内质网紧张诱导的神经元
凋
亡进行分析；④运用干细胞移植治疗心肌坏死和促进新血管形成；⑤证明Notch信号传导
调
节血管重塑过程和抑制寡突胶质细胞分化；⑥发现干扰素抑制寡突胶质细胞凋亡；⑦发
现
p53和bcl-2基因对DNA损伤诱导细胞凋亡的调控作用及其对胚胎发育的影响。

 

代表论文：

A. Research papers (*Correspondence author)

 1.    Xiong X, Qi X, Ge XM, Gu P, Zhao J, Zhao QS, *Gao X.(2007) A novel 
Phex
 mutation with defective   glycosylation causes hypophosphatemia and rickets 
i
n mice. J Biomed Sci, in press

2.      Sha HB, Xu J, Tang J, Ding J, Gong JF, Ge XM, Kong D, *Gao X. (2007) 
D
isruption of a novel regulatory locus results in decreased Bdnf expression, 
ob
esity and type 2 diabetes in mice. Physiological Genomics, in press

3.       Qi X, Yang G, Yang L, Lan Y, Weng T, Wang J, Wu Z, Xu J, *Gao X, 
*Yan
g X. (2007)Essential role of Smad4 in maintaining cardiomyocyte 
proliferation 
during murine embryonic heart development. Dev Biol, in press

4.       Zeng H, Di L, Fu GP, Chen YH, Gao X, Xu L, Lin X, Wen RR (2007) 
Phosp
horylation of Bcl10 negatively regulates T cell receptor-mediated NF-kB 
activa
tion. Mol Cell Biol, 27:5235-45

5.       Liu X, Chen Y, Zhang F, Chen L, Ha T, Gao X, Li C. Synergistically 
th
erapeutic effects of VEGF165 and angiopoietin-1 on ischemic rat myocardium. 
Sc
and Cardiovasc J. 2007 Apr;41(2):95-101.

6.       Hua F, Ha T, Ma J, Li Y, Kelley J, Gao X, Browder IW, Kao RL, 
William
s DL, Li C (2007) Protection against Myocardial Ischemia/Reperfusion Injury 
in
 TLR4-Deficient Mice Is Mediated through a Phosphoinositide 3-Kinase-
Dependent
 Mechanism. J Immunol, 178:7317-24.

7.       Liu L, Zhang X, Qian B, Min X, Gao X, Li C, Cheng Y, Huang J (2007) 
O
ver-expression of heat shock protein 27 attenuates doxorubicin-induced 
cardiac
 dysfunction in mice. Eur J Heart Fail., in press

8.       Tan X, Weng T, Zhang J, Wang J, Li W, Wan H, Lan Y, Cheng X, Hou N, 
L
iu H, Ding J, Lin F, Yang R, Gao X, Chen D, Yang X（2007）Smad4 is required 
fo
r maintaining normal murine postnatal bone homeostasis. J Cell Sci 120: 2162-
2
170;

9.       Chen JY, Schopf JW, Bottjer DJ, Zhang CY, Kudryavtsev AB, Tripathi 
AB
, Wang XQ, Yang YH, Gao X, Yang Y (2007) Raman spectra of a Lower Cambrian 
cte
nophore embryo from southwestern Shaanxi, China. PNAS  104: 6289-6292;

10.     Zhang D, Zhang F, Zhang Y, Gao X, Li C, Yang N, Cao K (2007) 
Combining
 erythropoietin infusion with intramyocardial delivery of bone marrow cells 
is
 more effective for cardiac repair. Transpl Int. 20:174-83.

11.     Fan Y, Liu X, Zhang H, Dai J, Zhang X, Zhu M, Gao X, Wang Y (2006) 
Var
iations in exon 7 of the MSH2 gene and susceptibility to gastrointestinal 
canc
er in a Chinese population. Cancer Genet Cytogenet. 170:121-8.

12.     Gu X, Xu F, Song W, Yang Y, Hu P, Wang X, Gao X, Zhao Q (2006) A 
novel
 cytochrome P450, zebrafish Cyp26D1, involved in metabolism of all-trans 
retin
oic acid, Molecular Endocrinology, 20:1661-72.

13.     Chen JY, Bottjer DJ, Davidson EH, Dornbos SQ, Gao X, Li CW, Yang YH, 
L
i G, Wang XQ, Xian DC, Wu RH, Hwu YK (2006) Phosphatized polar-lobe-forming 
em
bryos from the Precambrian of southwest China. Science, 312: 1644-1646

14.     Zhang D, Zhang F, Zhang Y, Gao X, Li C, Ma W, Cao K. (2006) 
Erythropoi
etin enhances the angiogenic potency of autologous bone marrow stromal cells 
i
n a rat model of myocardial Infarction. Cardiology. 108:228-236

15.     Yu M, Sha H, Gao Y, Zeng H, Zhu M, Gao X* (2006) Alternative 3’ UTR 
p
olyadenylation of Bzw1 transcripts display differential translation 
efficiency
 and tissue-specific expression. Biochem Biophys Res Commun. 345:479-85

16.     Yang CX, Chen HQ, Chen C, Yu WP, Zhang WC, Peng YJ, He WQ, Wei DM, 
Gao
 X, Zhu MS (2006) Microfilament-binding properties of N-terminal extension 
of 
the isoform of smooth muscle long myosin light chain kinase. Cell Res, 
16:367-
76

17.     Zhu Y, Zeng H, Gao X, Lu ZH (2006) Quantitative analysis of EcoR1 
meth
ylase-DNA complex by atomic force microscopy. Scanning 28: 15-19

18.     Ha T, Li Y, Gao X, McMullen JR, Shioi T, Izumo S, Kelley JL, Zhao A, 
H
addad GE, Williams DL, Browder IW, Kao RL, Li C. (2005) Attenuation of 
cardiac
 hypertrophy by inhibiting both mTOR and NFkB activation in vivo.  Free 
Radica
l Biology & Medicine, 39:1570-80

19.     Hua F, Ha T, Ma J, Gao X, Kelley J, Williams DL, Browder IW, Kao RL, 
L
i C.(2005) Blocking the MyD88-dependent pathway protects the myocardium from 
i
schemia/reperfusion injury in rat hearts. Biochem Biophys Res Commun. 
338:1118
-25

20.     Ha T, Hua F, Li Y, Ma J, Gao X, Kelley J, Zhao A, Haddad GE, 
Williams 
DL, Browder IW, Kao RL, Li C. (2005) Blockade of MyD88 Attenuates Cardiac 
Hype
rtrophy and Decreases Cardiac Myocyte Apoptosis in Pressure Overload Induced 
C
ardiac Hypertrophy in vivo. Am J Physiol Heart Circ Physiol., 290(3):H985-94

21.     Ha T, Li Y, Hua F, Ma J, Gao X, Kelley J, Zhao A, Haddad GE, 
Williams 
DL, William Browder I, Kao RL, Li C. (2005) Reduced cardiac hypertrophy in 
tol
l-like receptor 4-deficient mice following pressure overload. Cardiovasc 
Res. 
68:224-34.

22.     Gu X, Xu F, Wang X, Gao X, Zhao Q. (2005) Molecular cloning and 
expres
sion of a novel CYP26 gene (cyp26d1) during zebrafish early development. 
Gene 
Expr Patterns 5:733-9

23.     Yang G, Cui F, Hou N, Chen X, Zhang J, Wang Y, Jiang N, Gao X, Yang 
X 
(2005) Transgenic Mice That Express Cre Recombinase in Differentiated 
Hypertro
phic Chondrocytes, Genesis, 42:33-6

24.     Ruan H, Zhang N, *Gao X (2005) Identification of a novel point 
mutatio
n of mouse proto-oncogene c-kit through N-ethyl-N-nitrosourea (ENU) 
mutagenesi
s. Genetics, 169:819-31

25.     Zhou L, Ma W, Yang Z, Zhang F, Lu L, Ding Z, Ding B, Ha T, *Gao X, 
*Li
 C. (2005)　VEGF(165) and angiopoietin-1 decreased myocardium infarct size 
thr
ough phosphatidylinositol-3 kinase and Bcl-2 pathways. Gene Ther. 12:196-202

26.     Wu X, Zeng H, Zhang X, Zhao Y, Sha H, *Gao X, *Xu Q. (2004) PRL-3 
prom
otes motility and metastasis of mouse melanoma cells.  Am J. Path. 164: 2039

27.     Wen C, Xue B, Qin X, Yu M, Zhang M, Zhao D, Gao X, Gu J, Li C. 
(2004) 
NRAGE suppress cell proliferation though a p53 dependent pathway. FEBS Lett. 
5
64: 171

28.     Li C, Ha T, Gao X, Kelley J, Browder W, Williams DL. (2004) NFkB 
activ
ation is required for the development of cardiac hypertrophy in vivo. Am J 
Phy
s: Heart and Circulatory Physiology. 287 : H1712

29.     Li C, Ha T, Kelley J, Gao X, Qiu Y, Kao RL, Browder W, Williams DL. 
(2
004) Modulating Toll-like receptor mediated signaling by (1-->3)-beta-d-
glucan
 rapidly induces cardioprotection. Cardiovasc Res. 61:538

30.     Zhu Y, Zheng H, Xie JM, Ba L, Gao X, Lu Z (2004) AFM studies on DNA 
st
ructural changes induced by vincristine sulfate and aspirin. Microscopy and 
Mi
croanalysis 10:286

31.     Zhang F, Yang Z, Chen Y, Qin J, Zhu T, Xu D, Xu Z, Xu Q, Qian Y, Ma 
W,
 Chen L, Gao X, Li C, Ha T, Kao RL. (2003) Clinical cellular 
cardiomyoplasty: 
technical considerations. J Card Surg.18:268

32.     He F, Wang Z, Zhao J, Bao J, Ding J, Ruan H, Xie Q, Zhang Z, *Gao X. 
(
2003) Large- scale screening of disease model through ENU mutagenesis in 
mice.
 Chinese Science Bulletin. 24:2665

33.     Kao RL, Zhang FM, Yiang ZJ, Gao X, Li CF (2003) Cellular 
cardiomyoplas
ty using autologous satellite cells: from experimental to clinical study. 
Basi
c Appl. Myol. 13:1

34.     Zhang F, Chen Y, Yang Z, Gao X, Ma W, Li C, Kao RL (2003) Cellular 
car
diomyoplasty for a patient with heart failure. Cardiovascular Radiation 
Medici
ne 4: 43

35.     Zhang F, Gao X, Yiang ZJ, Ma W, Li C, Kao RL (2003) Cellular 
cardiomyo
plasty: A preliminary clinical report. Cardiovascular Radiation Medicine 4: 
39

36.     Jiang P, Chen L, Liu J, Ding J, Gao X and Guo ZJ (2002) Novel zinc 
flu
orescent probe bearing dansyl and aminoquinoline groups. Chemical 
Communicatio
n 2002:1424

37.     Chen LZ and *Gao X (2002), Neuronal apoptosis induced by endoplasmic 
r
eticulum stress. Neurochemical Research, 27:891

38.     McCright B, Gao X, Shen L, Lozier J, Lan Y, Maguire M, Herzlinger D, 
W
eimaster G, Jiang R and Gridley T. (2001) Defects in development of the 
kidney
, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 
mutati
on. Development, 128:491  

39.     Gao X, Gillig TA, Ye P, D’Ercole AJ, Matsushima GK and Popko B. 
(2000
) Interferon-gamma protects against Cuprizone-induced demyelination.  Mol & 
Ce
ll Neurosci. 16:338-49

40.     Xue Y, Gao X (co-first author), Lindsell CE, Norton CR, Chang B, 
Hicks
 C, Gendron-Maguire M, Rand EB, Weinmaster G and Gridley T (1999) Embryonic 
Le
thality and vascular defects in mice lacking the Notch ligand Jagged 1.  Hum 
M
ol Genet 8:723-30

41.     Gao X, Copeland NG, Gilbert DJ, Jenkins NA and Gridley T, (1998) 
Assig
nment of the murine Notch2 and Notch3 gense to chromosomes3 and 17. Genomics 
4
9:60-1

42.     Wubah JA,Ibrahim MM,Gao X, Pisano MM and Knudsen TB (1996) Teratogen-
i
nduced eye defect is mediated by p53-dependent embryonic apoptosis. Current 
Bi
ology 6:60-9

43.     Gao X, Knudsen TB, Ibrahim MM and Haldar S. (1995) Bcl-2 relieves 
deox
yadenylate stress and suppresses apoptosis in pre-B leukemia cells. Cell 
Death
 and Differentiation 2:69-77

44.     Gao X, Blackburn MR and Knudsen TB. (1994) Activation of apoptosis 
by 
2'-deoxyadenosine in mouse early postimplantation embryos. Teratology 49:1-12

45.     Blackburn MR, Gao X, Airhart MJ, Skalko RG, Thompson LF, Knudsen TB. 
(
1992) Adenosine levels in the postimplantation mouse uterus: quantitation by 
H
PLC-fluorometric detection and spatiotemporal regulation by 5'-nucleotidase 
an
d adenosine deaminase. Dev Dyn. 194:155-68

46.     Liu JN, Lu L, Gao X, Wang J, Zhu D, Lai LH, Xu XJ, Tang YQ. (1992) 
The
 structure basis of the poor fibrin specificity of urokinase (I)-
knowledgebase
d prediction of Kringle structures of urokinase and its related proteins. 
Sci 
China, Series B, 35:176-82

47. 郑一守, 秦国强, 高翔, 刘杰, 丁琪, 张梅芬, 姚建华 (1986)  抗体形成细胞发育
的
免疫组织化学研究．实验生物学报，19 : 327—337

 

B.Books and reviews:

1.  高翔：小鼠ENU化学诱变和QTL分析在疾病研究中的应用，in 基因工程小鼠，p95-
115
，傅继梁主编，上海科学技术出版社

2．高翔，迟慧梅：生命的起源与进化，p92-97；高翔：生物技术在医学中的应用，
p118-
126，in 生物医学导论，吴观陵主编，人民卫生出版社

3．Gao X, Kemper A and Popko B. (1999) Advanced transgenic and gene-
targeting 
approaches. Neurochem. Res. 24:1181-8

实验室成员：

技术员: 李瑶

悦，齐心，周玥，蒋璇，闫果林，陈辉，卢在恋，魏晓为，杨军。

 

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