细胞为什么生长和分裂？一般生长机制及其定义 细胞的生长、繁殖和代谢特性

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摘要翻译：
我们考虑一个一般的生长机制，它在细胞水平和以上（器官、系统和整个生物体）起作用。利用生长方程的数学表示，研究了变形虫和裂殖酵母粟酒裂殖酵母的生长和分裂机理。我们展示了这种机制如何与生物分子机制一起，控制细胞的生长和繁殖，尤其是这些有机体。这一机制为生物学的基本问题提供了揭示性的答案，如细胞为什么生长和分裂，为什么以及何时停止生长。它还揭示了生命为什么以及如何起源和发展的问题。通过对生长方程的求解，得到了裂变酵母生长曲线随几何特性和RNA和蛋白质合成所需营养物流入量的解析表达式，并将计算得到的生长曲线与85个实验结果进行了比较。统计评价表明，这些生长曲线与实验数据的对应性明显优于以往的所有近似。此外，利用一般的生长机制，我们展示了细胞的代谢特性，它们的大小和进化特性之间的关系，考虑到裂变酵母。特别是，我们发现裂变酵母S.pombe消耗约16-18倍的营养维持需要比生物量合成。
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英文标题：
《Why cells grow and divide? General growth mechanism and how it defines
  cells' growth, reproduction and metabolic properties》
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作者：
Yuri K. Shestopaloff
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最新提交年份：
2016
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  We consider a general growth mechanism, which acts at cellular level and above (organs, systems and whole organisms). Using its mathematical representation, the growth equation, we study the growth and division mechanisms of amoeba and fission yeast Schizosaccharomyces pombe. We show how this mechanism, together with biomolecular machinery, governs growth and reproduction of cells, and these organisms in particular. This mechanism provides revealing answers to fundamental questions of biology, like why cells grow and divide, why and when cells' growth stops. It also sheds light on questions like why and how life originated and developed. Solving the growth equation, we obtain analytical expression for the growth curve of fission yeast as a function of geometrical characteristics and nutrient influxes for RNA and protein synthesis, and compare the computed growth curves with 85 experiments. Statistical evaluation shows that these growth curves correspond to experimental data significantly better than all previous approximations. Also, using the general growth mechanism, we show how metabolic characteristics of cells, their size and evolutionary traits relate, considering fission yeast. In particular, we found that fission yeast S. pombe consumes about 16-18 times more nutrients for maintenance needs than for biomass synthesis.
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PDF链接：
https://arxiv.org/pdf/1610.01404

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关键词：Quantitative Reproduction Evolutionary Mathematical Presentation cells 维持 yeast 方程 展示