发布时间：2015-04-01 来源：人大经济论坛

制药工程论文范文 目 录 中文摘要Ⅰ 英文摘要Ⅱ 目录Ⅲ 1. 绪论1 1.1 三氟乙酸乙酯的介绍1 1.2 项目概况1 1.3 反应精馏技术的发展史2 1.3.1 反应精馏技术的应用范围3 1.3.2 反应精馏的操作工艺3 1.3.3 反应精馏的适用条件和工业要求4 1.4 本文的研究目的及研究内容4 2. 实验部分5 2.1 实验试剂及实验仪器5 2.2 实验装置5 2.3 制备原理6 2.4 反应精馏工艺流程7 2.4.1 三氟乙酸乙酯的物系性质7 2.4.2反应精馏合成三氟乙酸乙酯的工艺流程8 2.4.3产品的分析9 2.4.4计算公式11 3. 结果与讨论12 3.1实验结果12 3.2催化剂用量的影响13 3.3三氟乙酸与乙醇摩尔比的影响16 3.4回流比的影响17 3.5小结19 4总结和展望21 致谢22 参考文献23 摘 要：用传统工艺制备三氟乙酸乙酯存在原料消耗大、能耗高、设备投资大、生产周期长、产品纯度低和操作难度高等缺点。本文在对三氟乙酸乙酯生产体系各物性特点分析的基础上，引入反应精馏技术，将化学反应和精馏分离结合在一个设备中同时进行，减少了设备投资，实现了连续化生产。以三氟乙酸、乙醇为原料，以浓硫酸为催化剂，对反应精馏法制备三氟乙酸乙酯的过程进行了实验研究。着重考察了回流比、配料比、反应温度、催化剂用量等因素对三氟乙酸乙酯的收率和产品中三氟乙酸乙酯含量的影响，并得出最佳的工艺条件。 关键词： 三氟乙酸乙酯；三氟醋酸；乙醇；反应精馏 Abstract: Preparation of ethyl trifluoroacetate (TFAE) with traditional procedures had many disadvantages such as the raw materials waste, high energy consumption, amounts of equipment’s investments, long production period, difficult operation, etc. The reactive distillation method was introduced based on analysis of every component’s characteristics in the production system of TFAE. Combined reaction with distillation, the equipment’s investments was reduced and the production would be carried continuously. Preparation of TFAE through reactive distillation process had been researched, with trifluoroacetic acid and ethanol as raw materials, concentrated sulfuric acid as the catalyst. The experiments were focused on the reflux ratio, the mole ratio of components, reaction temperature, amount of catalyst and other factors influencing the yield and purity of TFAE, Finally, the optimum reaction conditions were obtained. Key words: Ethyl trifluoroacetate; Trifluoroacetic acid; Ethanol; Reactive distillation